Research on acute mastitis with intoxication in regard to adjusted treatment regimes Print E-mail

{mosimage}Peracute to acute mastitis requires fast and optimal therapy. Without an optimized therapy a lethal end can occur because of intoxication or the cow survives, but the affected udder quarters are seriously damaged. After these events additional complications like left displacement of the abomasum, ketosis or liver fatty degeneration can occur.


Project coordinator: Dr. Leopold Podstatzky-Lichtenstein

Aim of this project is to create a clinical score following the clinical score in diarrhoetic calves (Lorenz, 2004), to find out the degree of intoxication in peracute to acute mastitis in the field. It is possible to compare the clinical signs to the degree of intoxication and the degree of mastitis. Based on these data the ideal therapy is started and the verification of the recovery occurs. By forming groups it is determined which method results in best recovery, noticed in feed intake and milk production, to minimize the loss for the farmer.

The so called Colimastitis is a case of emergency, because this form of mastitis represents a highly acute disease and the therapy will only be promising if it is applied in the first hours. The inflammation and the effect of toxine either lead to the death of the animal or the animal comes through this phase, but mostly a normalization of the udders will only very slowly take place, very often not even in the same period of lactation. Without any therapy this disease shows a high rate of death.

The control of the germs causes the release of a large amount of endotoxines, which are extremely toxical or even lethal for the host, because they can cause a septic shock. The clinical picture and the pathophysiology are very complex. Additionally to the eventually used antibiotical treatment a non-steroidal antiphlogistic is advised, but shows different effects in several studies. Some clinical symptoms could be improved by the additional therapy. Indicators of inflammation in the milk or at milk production showed both significant and not significant changes. Grandemange et al. (2002) suggested another additional therapy of infusions.

Hypertonic solutions effectuate an enlargement of the plasma-volume, raise the performance of the heart and improve the release of oxygen into the tissue.

The severity code of the intoxication is not to be determined by means of a single parameter. The reason of a mastitis can be ascertained by a bacteriological milk-examination. However, this doesn´t say anything about the grade or the dimension of the mastitis. By means of the investigated data of this project and the clinical score correlations and characteristics between the degree of intoxication, severity of inflammation and clinical status should be appointed.

By means of a division into 3 groups (without infusion, isotonic and hypertonic infusion) it is examined, whether infusions are necessary and if yes, in which concentration they are suitable to support the recovery of the cow in the frame of the therapy.

An early optimal therapy is absolutely necessary at acute parenchymatous mastitis in order to avoid death and to achieve a regeneration as fast as possible (eating and milk-performance).